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Journal: PeerJ
Article Title: Prediction of prognosis and treatment effect of cervical cancer by immunogenic cell death-related genes
doi: 10.7717/peerj.21635
Figure Lengend Snippet: (A) UniCox analysis was performed to identify prognostic genes: Visualization of HR values in forest map, green represents low-risk genes, red represents high-risk genes. (B) The graph of lasso regression. (C) The graph of cross validation. (D), (E) ROC curves corresponding to prediction models in TCGA database (G) and GEO database (H). TCGA verification & GEO verification based on the patient’s risk score, the sample was divided into two groups: high and low risk, with low risk shown in blue and high risk in red. The abscissa is the survival time and the ordinate is the survival rate. (F) Risk curve: the abscissa represents the sorted samples. Risk curve: the vertical axis represents the risk score. The risk to patients increases from left to right. According to the median risk score of the patients, the sample was divided into high- and low-risk groups, with the low-risk group represented in green and the high-risk group represented in red. In the small graph survival state, the ordinate represents the survival time. The points in the graph are shown in red for patients who died and in green for those who survived. As the risk to patients increases, the risk of death also increases, ATG5, IL-1B, PDIA3, and TNF were high-risk genes, while FOXP3 and IFNG were low-risk genes. (I) Univariate COX regression analysis: risk score is correlated with patient outcome. (J) Multivariate COX regression analysis showed that risk scores could be used as independent prognostic predictor.
Article Snippet: The sections were incubated overnight at 4 °C with primary
Techniques: Analysis, Biomarker Discovery
Journal: PeerJ
Article Title: Prediction of prognosis and treatment effect of cervical cancer by immunogenic cell death-related genes
doi: 10.7717/peerj.21635
Figure Lengend Snippet: (A) ATG5 expression in normal cervical tissues. (B) ATG5 expression in CC. (C) PDIA3 expression in normal cervical tissues. (D) PDIA3 expression in CC.
Article Snippet: The sections were incubated overnight at 4 °C with primary
Techniques: Expressing